One step from chemical automatons

One step forward

One step forwards, one step back.

One-step, one-lane chemical DNA sequencing by N-methylformamide in the presence of metal ions.

We report on a chemical method that allows DNA sequencing by a single reaction. It is based on treatment of 5'-end-labeled DNA with N-methylformamide in the presence of manganese. This method allows the manipulation of samples to be kept to a minimum and consists of a single chemical step that requires about 30 minutes to complete base degradation, phosphodiester bond cleavage and denaturation....

One-Step Thermo-Chemical Synthetic Method for Nanoscale One-Dimensional Heterostructures

Inspired by the discovery of carbon nanotubes in 1991, enormous research efforts have been made on one-dimensional (1-D) nanostructures, such as nanowires, nanotubes, and nanobelts. Among them, 1-D nanoscale heterostructures (HS) with modulated structure, compositions, and interfaces have become of particular interest, 6–10 which represent an important class of nanoscale building blocks with su...

Religiosity and telomere length: One step forward, one step back.

a Harvard T.H. Chan School of Public Health, Department of Epidemiology, Program on Integrative Knowledge and Human Flourishing, Harvard University, National Consortium on Psychosocial Stress, Spirituality, and Health, United States b Harvard Medical School, Harvard/MGH Center on Genomics, Vulnerable Populations, and Health Disparities, National Consortium on Psychosocial Stress, Spirituality, ...